The Human Rights Campaign is the largest LGBTQ advocacy group and political lobbying organization in the United States.

The Transgender Law Center is the largest American transgender-led civil rights organization in the United States.

Lambda Legal Defense and Education Fund, better known as Lambda Legal, is an American civil rights organization that focuses on lesbian, gay, bisexual, and transgender communities as well as people living with HIV/AIDS through impact litigation, societal education, and public policy work.

GLAAD is an American non-governmental media monitoring organization, founded as a protest against defamatory coverage of LGBT people. Its agenda has since extended to the entertainment industry and its portrayal of these groups.

PFLAG is the United States' first and largest organization uniting parents, families, and allies with people who are lesbian, gay, bisexual, transgender, and queer. PFLAG National is the national organization, which provides support to the PFLAG network of local chapters.

The National Center for Transgender Equality is a nonprofit social equality organization founded in 2003 by transgender activist Mara Keisling in Washington, D.C.

The Sylvia Rivera Law Project is a legal aid organization based in New York City at the Miss Major-Jay Toole Building for Social Justice that serves low-income or people of color who are transgender, intersex and/or gender non-conforming.

It Gets Better is an Internet-based 5013 nonprofit founded in the United States by gay activist, author, media pundit, and journalist Dan Savage and his husband Terry Miller.

NCLR is a national legal organization committed to advancing the civil and human rights of lesbian, gay, bisexual, and transgender people and their families through litigation, legislation, policy, and public education.

Family Equality is a national American nonprofit organization whose mission is to advance legal and lived equality for lesbian, gay, bisexual, transgender and queer families, and for those who wish to form them, through building community, changing hearts and minds, and driving policy change.

Point Foundation is a scholarship fund that provides financial aid for lesbian, gay, bisexual, transgender, and queer college aspiring individuals in the United States.

Equality Federation is a social justice, advocacy and capacity building organization serving and supporting state-based lesbian, gay, bisexual and transgender advocacy organizations in the United States.